I've seen throught the game that you can improve your relationship status by many ways (Presents, quests, birthdays, etc.), but only a few to make them angry, as much as i know looking into their garbage and throwing them rocks with the slingshot, but you can't actually make them hate you, they will at most ignore you. I will like to see a mod or even a game feature where you COULD actually be a real mad man and see them getting annoyed with you. Any mad man/woman outhere? xD